A Mission to Improve Cardiovascular Health

- A message from Rainer Boger, M.D. - 

Beginning in the 1980’s, a series of exciting discoveries were made that greatly influenced the way we can improve our cardiovascular health. It all started in 1981 when Robert Furchgott, and his group from New York, discovered that the ability of arteries to dilate (become wider and more flexible) strictly depended on the presence of the innermost layer of cells, the so-called endothelial cells.

Lou Ignarro, along with his research group from Los Angeles, was able to prove that the volatile compound released from endothelial cells upon stimulation is nitric oxide, a gas produced from L-arginine. It was Ferid Murad, from Stanford University, who finally discovered the mechanism by which nitric oxide exerts its beneficial effects in the vascular wall.

With 22 years of basic and applied clinical research experience, I have made it my mission to use the discovery of these biological mechanisms to develop novel ways of enhancing cardiovascular health. As a clinical physician, I have treated patients who suffered from severe lack of blood flow to the legs, and it is this experience that has inspired me to research the benefits of L-arginine and its affect on tissue blood flow.

L-arginine is the precursor of nitric oxide, and people who are deficient in L-arginine have an increased risk of cardiovascular concerns. Based on our clinical studies, we believe that enhanced L-arginine in the blood will improve vascular function and vascular health. This knowledge makes L-arginine unique among the near 250 amino acids that have biological function.

When using L-arginine as a dietary supplement, there are a few caveats that need to be considered. Restoring nitric oxide formation with L-arginine needs to be maintained around the clock. L-arginine, however, has a short residence time in blood; in less than 1 hour, half is already spent. Only when L-arginine is combined with L-citrulline is it possible to provide prolonged elevations of L-arginine in the blood stream.

Furthermore, cardiovascular health is a refined balance in which the endothelial cells interact with oxidative factors, blood platelets and the coagulation system, and transcriptional regulation of cell growth and development. Thus, additional components can interact with L-arginine to promote cardiovascular health on a multifactorial level.

With its unique blend of l-arginine and other supportive ingredients, it is my experience that Synergy’s ProArgi-9+ provides an optimized way to enhance your cardiovascular system compared to other nutritional supplements on the market.

Rainer Boger, M.D.
Medical Advisory Board Member

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